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KMID : 0371420160910060278
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Annals of Surgical Treatment and Research
2016 Volume.91 No. 6 p.278 ~ p.287
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Medullary thyroid carcinoma: a 30-year experience at one institution in Korea
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Lee Cho-Rok
Lee So-Hee
Son Hai-Young
Ban Eun-Jeong
Kang Sang-Wook
Lee Jan-Dee
Jeong Jong-Ju
Nam Kee-Hyun
Chung Woong-Youn
Park Cheong-Soo
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Abstract
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Purpose : The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea.
Methods : We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012.
Results : In all, 65 patients (76.5%) had sporadic MTC and 20 patients (23.5%) had hereditary MTC. Patients in the sporadic group were older than in the hereditary group (P < 0.001). However, the hereditary group had more tumor multiplicity (P < 0.001) and bilaterality (P < 0.001). Neither survival rate was significantly different between the sporadic and hereditary groups (P = 0.775 and P = 0.866). By multivariate analysis, distant metastasis was a significant prognostic factor for overall and progression-free survival.
Conclusion : In general, patients with MTC have favorable outcomes. Distant metastasis appears to be the strongest predictor of overall and progression-free survival.
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KEYWORD
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Familial medullary thyroid carcinoma, Prognosis, Survival
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